Factors affecting failure of irrigation and debridement with liner exchange in total knee arthroplasty infection

Reoperation-free survival following I&D with polyethylene liner exchange of acutely infected primary TKA: 1) improves with increased postoperative antibiotic therapy duration so chronic antibiotic suppression should be considered following TKA I&D with liner exchange; 2) is worse with atrial fibrillation, COPD, > 15 cells/HPF, preoperative C-reactive protein > 500 mg/L, or MRSA so two-stage revision may be favored in these patients; and 3) is equivalent in acute postoperative and hematogenous infections.