A new vaccine against tuberculosis shows greater protection in a mouse model with progressive pulmonary tuberculosis

Conclusions: This study showed that rBCG38 vaccine induced a strong Th1 response, demonstrated by the high levels of IL-2 and IFN-γ producer cells and IgG2a. Protection was mediated for as long as 6 and 4 months after challenge with M. tuberculosis H37Rv and Beijing genotypes, respectively.