کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8978220 | 1106586 | 2005 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lymphoid follicles of different phenotype appear in ileum during involution of the sheep ileal Peyer's patch
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کلمات کلیدی
GALTJPPPCNAFAEperiodic acid-Schiff reagentIPPFDCTBSPBSDABBSA - BSAbovine serum albumin - آلبومین سرم گاوProliferating Cell Nuclear Antigen - آنتیژن هسته ای تکثیر سلولیInvolution - انفجارfollicle-associated epithelium - اپیتلیوم مرتبط با فولیکولgut-associated lymphoid tissue - باکتری لنفوئیدی مرتبط با رودهTris buffered saline - تریس نمک بافرfollicular dendritic cell - سلول های دندریتیک فولیکولارPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریPAS - نهHematoxylin and Eosin - هماتوکسیلین و ائوزینIleal Peyer's patch - پایتل ایلیال پایرSheep - گوسفند
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
The ileal Peyer's patch (IPP) of young sheep is a site of diversification of the primary antibody repertoire and where involution takes place at young age. Tissue samples from the ileum were collected in 134 animals aged from 1 month to 6 years, and IPP follicle phenotypes were characterised. We describe a new type of ileal lymphoid follicles that became relatively more frequent during involution, and had numerous intrafollicular T-cells and BAQ44A+ B-cells and large interfollicular T-cell areas. As opposed to classical IPP follicles in which the BAQ44A+ cells were confined to the narrow follicle-neck region, the novel atypical ileal lymphoid follicle had these cells distributed throughout the follicle. The relative distribution of cell types in the typical IPP follicle remained fairly constant during involution. Many animals older than 9 months (64/92) still had had typical IPP follicles and even sheep 4 years and older (5/9) had IPP-type follicles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental & Comparative Immunology - Volume 29, Issue 6, 2005, Pages 539-553
Journal: Developmental & Comparative Immunology - Volume 29, Issue 6, 2005, Pages 539-553
نویسندگان
Kai-Inge Lie, Mona Aleksandersen, Thor Landsverk,