کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8980679 | 1553781 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distribution of Leucocyte Subsets in Bronchial Mucosa from Dogs with Eosinophilic Bronchopneumopathy
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Immunohistochemistry was used to characterize the distribution of leucocyte subsets in the bronchial mucosa of 11 dogs with idiopathic eosinophilic bronchopneumopathy (EBP). Formalin-fixed tissues from all dogs were included in the study, but frozen tissue from only one dog was available. MHC class II+ cells were found in moderate numbers in the lamina propria (LP). These cells were morphologically either dendritic-like cells or macrophages, but many macrophages did not express MHC class II. Such molecules were expressed by occasional fibroblasts. L1+ cells, which formed a relatively small component of the LP inflammatory infiltrate, were morphologically either macrophages or polymorphonuclear cells (probably eosinophils). IgA+ plasma cells were found in varying numbers in the LP, mostly in association with glandular tissue. IgG+ plasma cells were less common, and IgM+ plasma cells were present in low numbers. Many CD3+ cells were present in the LP. In the single case from which frozen tissue was available, most of the lymphocytes were labelled with CD4 marker, while smaller numbers were CD8+ T cells. Most of the lymphocytes in this case were positively labelled with T-cell receptor (TCR)-αβ marker. TCR-γδ+ cells, although less common, were present in significant numbers throughout the LP. CDlc+ dendritic cells were numerous in the epithelium and in the LP, immediately beneath the basement membrane. These findings, which were similar to those described in human asthma, are suggestive of a Th2 dominant immune response in canine EBP. As in human asthma, this provides a possible basis for new forms of treatment in canine EBP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 133, Issues 2â3, AugustâOctober 2005, Pages 128-135
Journal: Journal of Comparative Pathology - Volume 133, Issues 2â3, AugustâOctober 2005, Pages 128-135
نویسندگان
D. Peeters, M.J. Day, C. Clercx,