کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8980784 1107743 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ectodysplasin-1 Deficiency in a German Holstein Bull associated with Loss of Respiratory Mucous Glands and Chronic Rhinotracheitis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
Ectodysplasin-1 Deficiency in a German Holstein Bull associated with Loss of Respiratory Mucous Glands and Chronic Rhinotracheitis
چکیده انگلیسی
A 2-year-old German Holstein bull was identified as a carrier of a mutation within the X-chromosomal ED1 gene, which encodes a TNF-related signalling molecule mainly involved in ectodermal development. The clinicopathological appearance was associated with hypotrichosis, hypodontia, and a reduced number of eccrine glands, in addition to chronic rhinotracheitis and partial squamous metaplasia. Furthermore, for the first time in an ED1-deficient animal, a complete lack of respiratory mucous glands was observed. This suggests that the ED1 gene plays a role in the development of mucous glands, the absence of which resembles a feature of X-linked anhidrotic ectodermal dysplasia (ED1) in human patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 132, Issue 4, May 2005, Pages 346-349
نویسندگان
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