کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8980820 | 1553782 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A Novel Leucodystrophy in a Dog
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
A diffuse, bilaterally symmetrical leucoencephalopathy was observed in a 2-month-old female crossbred puppy with a clinical history of progressive tetraparesis with front limb hypermetria, head tremor and seizures. Severe myelinolytic lesions with significant macrophage infiltration were confined to the white matter, mainly of the cerebellum and spinal cord. Moderate loss of myelin with severe gliosis predominated in the cerebrum. Axonal degeneration and axonal loss accompanied myelin degeneration. This disease was classified as a leucodystrophy. The clinical signs and certain features of the lesions (morphology and distribution), differed from those in previously described degenerative myelinolytic diseases in animals. The possible occurrence of the disorder in a littermate suggested a genetic basis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Comparative Pathology - Volume 132, Issues 2â3, FebruaryâApril 2005, Pages 232-236
Journal: Journal of Comparative Pathology - Volume 132, Issues 2â3, FebruaryâApril 2005, Pages 232-236
نویسندگان
S. Sisó, C. Botteron, A. Muhle, M. Vandevelde,