کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8985978 | 1110553 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Plasma pharmacokinetics and faecal excretion of ivermectin (Eqvalan® paste) and doramectin (Dectomax®, 1%) following oral administration in donkeys
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
Ivermectin (IVM- Eqvalan® paste, 1.87%) and doramectin (DRM-Dectomax® 1%) were each administered orally to donkeys at 200 μg kgâ1 bodyweight. Blood and faecal samples were collected at predetermined times over 30 days and plasma pharmacokinetics and faecal excretion determined. Maximum plasma concentrations (Cmax) of IVM (23.6 ng mlâ1) and DRM (33.9 ng mlâ1) were obtained at (tmax) 19.2 and 24 h, respectively. The area under the concentration curve (AUC) of DRM (228.9 ng day mlâ1) was significantly larger than that of IVM (119.3 ng day mlâ1) and mean residence time (MRT) was 6.5 days for IVM and 9.1 days for DRM. The highest (dry weight) faecal concentrations (9.33 μg gâ1 - IVM, 12.12 μg gâ1 - DRM) were detected at 55.9 and 48.0 h, respectively and each compound was detected (⩾0.05 μg gâ1) in faeces between 11 h and 9 days following oral administration in donkeys.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 79, Issue 3, December 2005, Pages 233-238
Journal: Research in Veterinary Science - Volume 79, Issue 3, December 2005, Pages 233-238
نویسندگان
C. Gokbulut, M. Boyacioglu, U. Karademir,