کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8993071 | 1113449 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Estimation of In Vivo Percutaneous Absorption of Emedastine from Bile Excretion Data Using a Deconvolution Method
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Estimation of In Vivo Percutaneous Absorption of Emedastine from Bile Excretion Data Using a Deconvolution Method Estimation of In Vivo Percutaneous Absorption of Emedastine from Bile Excretion Data Using a Deconvolution Method](/preview/png/8993071.png)
چکیده انگلیسی
In vivo percutaneous absorption of emedastine difumarate was investigated in rats and compared with rat skin in vitro. Since emedastine entering the systemic circulation is mostly excreted in bile, we first came up with the method of collecting bile with a minimal skin incision. In vivo skin permeation of the drug was estimated from biliary excretion data by deconvolution analysis. Prior to applying deconvolution analysis, it was confirmed that biliary excretion of emedastine was linear against its dose. When the in vivo permeation profile estimated by deconvolution was compared with the in vitro profile, the lag time for permeation was significantly shorter in vivo than in vitro, whereas the skin permeability coefficient was almost the same. If we presume a two-layer diffusion model, then this finding may primarily be due to the shorter diffusion length of the dermis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Metabolism and Pharmacokinetics - Volume 20, Issue 5, 2005, Pages 331-336
Journal: Drug Metabolism and Pharmacokinetics - Volume 20, Issue 5, 2005, Pages 331-336
نویسندگان
Shoichi Harada, Fumiyoshi Yamashita, Mitsuru Hashida,