کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998199 | 1115609 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alterations in GABAA receptor occupancy occur during the postnatal development of rat Purkinje cell but not granule cell synapses
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
The identification of synaptic GABAA receptors has proved difficult as neurones express multiple GABAA receptor subunits. For example, cerebellar granule cells express α1, α6, γ2, δ and β2/3 subunits and thus express many different GABAA receptor subtypes. Furthermore, the contribution of individual GABAA receptor subtypes is changed by developmental alterations in subunit expression. To further characterise the pharmacology of Golgi cell to granule cell synapses during development, the benzodiazepine-site ligand zolpidem was used. Zolpidem shows selectivity for α1βxγ2 receptors (x is any β subunit) and slows the decay and enhances the amplitude of α1βxγ2 receptor-mediated synaptic currents, provided the receptors are not fully occupied. For comparison, zolpidem was applied to Purkinje cell synapses, since the synaptic receptors are of known composition (α1βxγ2). At immature and adult Golgi cell to granule cell synapses, the decay of spontaneous and miniature inhibitory postsynaptic currents (sIPSCs and mIPSCs) was slowed by zolpidem but their amplitude and frequency were unaffected. At Purkinje cell synapses, although zolpidem slowed the decay of IPSCs at both immature and adult synapses, zolpidem only enhanced the amplitude of IPSCs at adult synapses. Thus during development, the level of receptor occupation remains constant at Golgi cell to granule cell synapses but falls at Purkinje cell synapses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 49, Issue 5, October 2005, Pages 596-609
Journal: Neuropharmacology - Volume 49, Issue 5, October 2005, Pages 596-609
نویسندگان
Mark J. Wall,