کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8998202 1115609 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of the antibiotic gentamicin on nicotinic acetylcholine receptors
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Effects of the antibiotic gentamicin on nicotinic acetylcholine receptors
چکیده انگلیسی
Medical treatment with the aminoglycosidic antibiotic gentamicin may produce side effects that include neuromuscular blockage and ototoxicity; which are believed to result from a dysfunction of nicotinic acetylcholine receptors (AChRs). Gentamicin is known to reversibly block ACh-currents generated by the activation of muscle-type αβγδ-AChR and neuronal α9-AChR. We studied the effects of gentamicin on heteromeric αβγδ-AChR and homomeric α7-AChR expressed in Xenopus oocytes. Prolonged treatment with gentamicin, and other antibiotics, differentially altered αβγδ- and α7-AChR responses. Specifically, gentamicin accelerated desensitization and did not reduce ACh-currents in oocytes expressing αβγδ-AChRs, whereas ACh-currents were reduced and desensitization was unaltered in oocytes expressing α7-AChRs. Moreover, acutely applied gentamicin acted as a competitive antagonist on both types of receptors and increased the rate of desensitization in αβγδ-AChR while reducing the rate of desensitization in α7-AChR. This data helps to better understand the action of gentamicin on muscle and nervous tissues, providing mechanistic insights that could eventually lead to improving the medical use of aminoglycosides.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 49, Issue 5, October 2005, Pages 627-637
نویسندگان
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