کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998401 | 1115627 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release](/preview/png/8998401.png)
چکیده انگلیسی
Different nicotinic acetylcholine receptor subtypes appear to modulate dopamine release from the striatum and prefrontal cortex. In this study a combination of subtype-selective antagonists and agonists were used to extensively characterize the nAChRs involved in dopamine release from slice preparations of these two brain regions. α-conotoxin-MII inhibited nicotine-evoked [3H]dopamine (DA) release from striatum by 45%, but did not affect cortical dopamine release. Neither methyllycaconitine, α-bungarotoxin, nor α-conotoxin-ImI affected nicotine-evoked [3H]DA release from either striatum or prefrontal cortex. MG 624, a novel selective nAChR antagonist, inhibited cortical [3H]DA by 53%, but had no effect on striatal release. Compared to nicotine, (±)-UB-165 showed less efficacy with respect to dopamine release from striatum, and had no effect on cortical dopamine release. (±)-UB-165-evoked striatal dopamine release was completely blocked by mecamylamine, partially blocked (up to 55%) by α-conotoxin-MII, and unaffected by methyllycaconitine or α-conotoxin-ImI. α4β2* and α6β2β3* nAChRs appear to play a role in striatal dopamine release, whereas α4β2* nAChRs modulate release from prefrontal cortex. α7* nAChRs do not appear to play a role in nAChR-mediated dopamine release from either brain region.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 48, Issue 1, January 2005, Pages 72-79
Journal: Neuropharmacology - Volume 48, Issue 1, January 2005, Pages 72-79
نویسندگان
Ying-Jun Cao, Carol S. Surowy, Pamela S. Puttfarcken,