کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998417 | 1115628 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Peripheral, but not central effects of cannabidiol derivatives: Mediation by CB1 and unidentified receptors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Peripheral, but not central effects of cannabidiol derivatives: Mediation by CB1 and unidentified receptors Peripheral, but not central effects of cannabidiol derivatives: Mediation by CB1 and unidentified receptors](/preview/png/8998417.png)
چکیده انگلیسی
We suggest that (+)-CBD analogues have mixed agonist/antagonist activity in the brain. Second, (â)-CBD analogues which are devoid of cannabinoid receptor affinity but which inhibit intestinal motility, suggest the existence of a non-CB1, non-CB2 receptor. Therefore, such analogues should be further developed as antidiarrheal and/or antiinflammatory drugs. We propose to study the therapeutic potential of (â)- and (+)-CBD derivatives for complex conditions such as inflammatory bowel disease and cystic fibrosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 48, Issue 8, June 2005, Pages 1117-1129
Journal: Neuropharmacology - Volume 48, Issue 8, June 2005, Pages 1117-1129
نویسندگان
Ester Fride, Datta Ponde, Aviva Breuer, Lumir Hanuš,