کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8998429 | 1115629 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacological and histological characterisation of nicotine-kindled seizures in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pharmacological and histological characterisation of nicotine-kindled seizures in mice Pharmacological and histological characterisation of nicotine-kindled seizures in mice](/preview/png/8998429.png)
چکیده انگلیسی
The present study reports that it is possible to induce kindling by repeated injections of nicotine. The newly characterised nicotine-kindling model was compared with that of pentylenetetrazole (PTZ) kindling. Mice were kindled by repeated injection of PTZ (37 mg/kg), or nicotine (2.3 mg/kg), and the effect of the anti-epileptic drugs (AED) levetiracetam (LEV), tiagabine (TGB) and phenytoin (PHT) on seizures in kindled and naïve mice were investigated. C-Fos immunoreactivity (Fos IR) was used to investigate differences in neuronal activity pattern between PTZ-, nicotine kindled and naïve animals. PTZ kindled animals mainly showed increased Fos IR in limbic regions, whereas Fos IR in nicotine kindled animals was increased in the entorhinal cortex, medial habenula and the compact part of substantia nigra. Fully kindled PTZ-induced seizures were inhibited by LEV (ED50 = 13.6 ± 7.8 mg/kg), TGB (ED50 = 0.3 ± 0.04 mg/kg) but not PHT (ED50 > 40 mg/kg) whereas fully kindled nicotine-induced seizures were inhibited by LEV (ED50 = 1.4 ± 0.4 mg/kg), TGB (ED50 = 0.3 ± 0.06 mg/kg) and PHT (ED50 = 9.2 ± 2.4 mg/kg). These differences in efficacy of AEDs were not due to changes in plasma levels in the various models. In conclusion, repeated administration of nicotine can induce a kindling-like phenomenon and the model showed significantly different Fos IR pattern and pharmacology to that of PTZ kindling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 48, Issue 7, June 2005, Pages 975-983
Journal: Neuropharmacology - Volume 48, Issue 7, June 2005, Pages 975-983
نویسندگان
Jesper F. Bastlund, David Berry, William P. Watson,