کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8999843 | 1116229 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vasodilative effect of perillaldehyde on isolated rat aorta
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
tetraethylammonium chlorideNG-nitro-l-arginine methyl esterPGF2αVasodilator effectl-NAME - L-NAMERat thoracic aorta - آئورت قفسه سینه موش صحراییNitric oxide. - اکسید نیتریک.norepinephrine - نوراپی نفرینProstaglandin F2α - پروستاگلاندین F2αPerillaldehyde - پریلالدئیدTEA - چایVoltage-dependent Ca2+ channel - کانال Ca2 + وابسته به ولتاژ
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Vasodilative effect of perillaldehyde on isolated rat aorta Vasodilative effect of perillaldehyde on isolated rat aorta](/preview/png/8999843.png)
چکیده انگلیسی
The vasodilative effect of perillaldehyde, one of the major oil components in Perilla frutescens BRITTON, was studied using isolated rat aorta. Perillaldehyde at final concentrations of 0.01 to 1 mM showed dose-dependent relaxation of the aorta contracted by treatment with prostaglandin F2α or norepinephrine. Neither the presence of NG-nitro-l-arginine methyl ester nor removal of the aortic endothelium affected the vasodilatation, suggesting that perillaldehyde exerts a direct effect on vascular smooth muscle cells. The vasodilative effect of perillaldehyde was not inhibited by pretreatment with a β-adrenergic receptor blocker (propranolol), an inhibitor of phosphodiesterase (theophylline), a delayed rectifier K+ channel blocker (tetraethylammonium chloride), or an ATP-sensitive K+ channel blocker (glibenclamide). However, perillaldehyde showed contrasting effects on vasodilatation of the aorta contracted by an influx of extracellular Ca2+ - perillaldehyde caused little vasodilatation on the aorta contracted by the Ca2+ ionophore A23187, while it inhibited the vasoconstriction induced by treatment with high-concentration K+, which dominantly opened the voltage-dependent Ca2+ channel. These results suggest that the vasodilative effect of perillaldehyde is derived from blocking the Ca2+ channels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Phytomedicine - Volume 12, Issue 5, 16 May 2005, Pages 333-337
Journal: Phytomedicine - Volume 12, Issue 5, 16 May 2005, Pages 333-337
نویسندگان
S. Takagi, H. Goto, Y. Shimada, K. Nakagomi, Y. Sadakane, Y. Hatanaka, K. Terasawa,