کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9000334 | 1116515 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of sodium fluoride on gastric emptying and intestinal transit in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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![عکس صفحه اول مقاله: Effect of sodium fluoride on gastric emptying and intestinal transit in mice Effect of sodium fluoride on gastric emptying and intestinal transit in mice](/preview/png/9000334.png)
چکیده انگلیسی
Fluoride, a well-recognised harmful substance, is easily absorbed by the gastrointestinal mucosa. It is therefore conceivable that any alteration of the gastrointestinal motility can affect the rate of absorption of fluoride and leads to aggravation of its toxic effects. The effects of fluoride on gastric emptying and intestinal transit were studied in the mouse using a carboxymethyl cellulose (CMC) solution as a non-nutrient meal. The participation of the cholinergic and nitrergic systems in these effects was also evaluated. Oral gavage of 5Â mM NaF had no significant effect on gastric emptying and intestinal transit of the CMC meal, whereas a decrease of gastric emptying (â33%, P<0.05) and an increase in intestinal transit (+20.7%, P<0.05) were observed with 20Â mM NaF. Atropine injection induced a significant decrease of gastric emptying. Combined treatment of atropine with 20Â mM NaF brought about a further, but not significant decrease in gastric emptying. N-G-nitro-l-arginine-methyl ester (L-NAME) treatment with or without oral administration of NaF decreased gastric emptying. Atropine treatment significantly depressed intestinal transit from 56.5% to 37.7% in the absence of NaF and from 70.1% to 42.8% in its presence. In contrast, L-NAME administration either alone or with fluoride increased intestinal transit (P<0.05). The present results suggest that fluoride alter gastrointestinal motility, an effect that may partly involve the cholinergic pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 57, Issue 1, 1 August 2005, Pages 59-64
Journal: Experimental and Toxicologic Pathology - Volume 57, Issue 1, 1 August 2005, Pages 59-64
نویسندگان
Smain Amira, Sihem Soufane, Kamel Gharzouli,