کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9021292 | 1561372 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A novel model for pathogenesis of autoimmune heart failure: The role of dendritic cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A novel model for pathogenesis of autoimmune heart failure: The role of dendritic cells A novel model for pathogenesis of autoimmune heart failure: The role of dendritic cells](/preview/png/9021292.png)
چکیده انگلیسی
Autoimmune diseases present a significant health challenge. Animal models of autoimmunity have shed great insight into both disease pathogenesis as well as into the workings of the immune system in general. Myocarditis is an autoimmune disease with epidemiological links to cardiotropic pathogens; however, many cases of the disease are sudden and unexplained. It has been proposed that a dysregulated adaptive immune response against cardiotropic pathogens can turn itself upon healthy human tissue, due to similarities between pathogenic and cardiac antigens. We discuss the critical role of dendritic cells (DCs) in the induction of myocarditis, and propose a model by which coincidental infection or cardiac tissue damage may represent the initial step in myocardial inflammation and subsequent myocarditis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1285, November 2005, Pages 192-201
Journal: International Congress Series - Volume 1285, November 2005, Pages 192-201
نویسندگان
Manu Rangachari, Urs Eriksson, Elisabeth H. Vollmann, Josef M. Penninger,