کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030065 | 1130717 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel protein targets for organophosphorus pesticides in rat brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel protein targets for organophosphorus pesticides in rat brain Novel protein targets for organophosphorus pesticides in rat brain](/preview/png/9030065.png)
چکیده انگلیسی
We report preliminary results from a proteomic search for rat brain protein targets adducted by organophosphorous pesticides. Azamethaphos, chlorfenvinphos, diazinon, malathion and chlorpyrifos oxons (in rat brain homogenates) or pirimiphos-methyl (after systemic treatment) were tested at levels producing no more than 30% inhibition of brain acetylcholinesterase. Loss of reactivity with tritiated diisopropylflurophosphate was taken as proof of adduction by the test organophosphate. In addition to acetylcholinesterase other, previously unrecognised, adducted proteins were detected in total brain protein extracts at 30, 32, 41, 71 and 83Â kDa. Azamethiphos adducted all but the 30 and 32Â kDa bands, but chlorpyrifos only acetylcholinesterase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 19, Issue 3, May 2005, Pages 451-454
Journal: Environmental Toxicology and Pharmacology - Volume 19, Issue 3, May 2005, Pages 451-454
نویسندگان
Andrea Murray, Alexandra J. Rathbone, David E. Ray,