کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030070 | 1130717 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Homology of assessment of visual function in human and animal models
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Homology of assessment of visual function in human and animal models Homology of assessment of visual function in human and animal models](/preview/png/9030070.png)
چکیده انگلیسی
To connect animal models with human neurobehavioral evaluations, it is necessary to understand the level of homology present between tests administered across species. This paper identifies four different levels of homology of assessment based on identity of measurement, function, and underlying neural substrate. These are discussed using detailed examples from toxicology of the visual system, with additional examples from tests of motor and cognitive function. This should provide a framework for considering both animal to human extrapolation and human to animal extrapolation, that is, how to import human experimental epidemiology findings into the lab for further work investigating mechanisms of toxicity. Designing neurobehavioral or sensory evaluations that permit easier extrapolation between human and animal models is necessary if we are to develop testing strategies that take advantage of mechanistic information at whole animal, in vitro, proteonomic, or genomic levels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 19, Issue 3, May 2005, Pages 485-490
Journal: Environmental Toxicology and Pharmacology - Volume 19, Issue 3, May 2005, Pages 485-490
نویسندگان
Andrew M. Geller,