کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9030234 1130726 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Substantial inhibition of chromate induced DNA-protein crosslink formation in vivo by α-lipoic acid
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Substantial inhibition of chromate induced DNA-protein crosslink formation in vivo by α-lipoic acid
چکیده انگلیسی
Cellular DNA-protein crosslink (DPCs) are the biologically active nucleoprotein complexes. Chromate compounds induce its formation. We have found that intraperitoneal-administration of α-lipoic acid (LA, a metabolic antioxidant) inhibited substantially the chromate induced DPCs formation in mouse peripheral blood lymphocytes (PBL). Change in LA administration schedule (i.e. pre-, co- or post-toxin) did not influence its effect. Results are of significance in two aspects viz. chemoprevention of chromate toxicity and exposure/effect estimation of chromate handling subjects. The antioxidant diet/therapy may mask the exposure/effect assessments and yield high frequency of false-negatives in study subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 20, Issue 1, July 2005, Pages 246-249
نویسندگان
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