کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030620 | 1130930 | 2005 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Subchronic and chronic safety studies with genistein in dogs
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is concluded that the administration of genistein to dogs for a period of 4-52Â weeks was well tolerated and did not result in systemic toxicity. Effects of genistein on the reproductive tract at very high doses were functional in nature and are of a type that would be expected in view of the relatively weak estrogenic activity of genistein and were considered not adverse effects. In the 4-week study, the no observed adverse effect level (NOAEL) for genistein was considered to be >500Â mg/kg/day and the no observed effect level (NOEL) was considered to be 150Â mg/kg/day. For the 52-week study, the NOAEL is considered to be >500Â mg/kg/day and the NOEL is considered to be 50Â mg/kg/day.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 10, October 2005, Pages 1461-1482
Journal: Food and Chemical Toxicology - Volume 43, Issue 10, October 2005, Pages 1461-1482
نویسندگان
R. Michael McClain, Erich Wolz, Alberto Davidovich, Friedlieb Pfannkuch, Jochen Bausch,