کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030649 | 1130932 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors
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کلمات کلیدی
Act-D, actinomycin DBPA, bisphenol A - BPA، بیسفنول AE2, 17β-estradiol - E2، 17β استرادیولNP, nonylphenol - NP، nonylphenolendocrine disrupters - اختلال غدد درون ریزer, estrogen receptor - است، گیرنده استروژنEstrogen - استروژنinsulin - انسولینPancreatic islets - جزایر پانکراسDMSO, dimethyl sulfoxide - دیمتیل سولفواکسیدRat - موش صحراییPCR, polymerase chain reaction - واکنش زنجیرهٔ پلیمراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors Promoting insulin secretion in pancreatic islets by means of bisphenol A and nonylphenol via intracellular estrogen receptors](/preview/png/9030649.png)
چکیده انگلیسی
In this study, we investigated the effects of endocrine disrupters bisphenol A (BPA) and nonylphenol (NP) on insulin secretion from rat pancreatic islets. Following acute exposure to BPA and NP, neither BPA nor NP (0.1, 1, 10, 100 and 1000 μg/l) affected insulin secretion in concentrations of 16.7 mM glucose. However, insulin secretion following long-term exposure to BPA or NP for 24 h in 16.7 mM glucose was significantly higher than without exposure. To determine whether increased insulin secretion resulting from long-term exposure to BPA and NP is induced via intracellular estrogen receptors, we blocked the cytosolic/nuclear estrogen receptors, using actinomycin-D (Act-D), an inhibitor of RNA synthesis, and ICI 182,780 (ICI), an estrogen receptor inhibitor. Following long-term exposure to BPA (10 μg/l) or NP (10 μg/l), Act-D or ICI treatment eliminated the facilitation of insulin secretion. In conclusion, we have demonstrated for the first time that long-term exposure to endocrine disrupters, such as BPA and NP, promotes in vitro insulin secretion from the pancreatic islets, via cytosolic/nuclear estrogen receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 5, May 2005, Pages 713-719
Journal: Food and Chemical Toxicology - Volume 43, Issue 5, May 2005, Pages 713-719
نویسندگان
Tetsuya Adachi, Koichiro Yasuda, Chisato Mori, Mariko Yoshinaga, Norihiko Aoki, Gozoh Tsujimoto, Kinsuke Tsuda,