کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9031370 | 1130976 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Xanthorrhizol has a potential to attenuate the high dose cisplatin-induced nephrotoxicity in mice
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کلمات کلیدی
XanthorrhizolNF-κB, nuclear factor-kappaBAP-1, activator protein 1 - AP-1، پروتئین فعال کننده 1EMSA, electrophoretic mobility shift assay - EMSA، روش تحرک حرکت الکتروفورتیکMDA, malondialdehyde - MDA، مالون دی آلدئیدTBA, thiobarbituric acid - TBA، اسید تیوباربیتوریکcisplatin - سیس پلاتینTranscription factors - عوامل رونویسیNephrotoxicity - نفخ سمیBUN, blood urea nitrogen - نیتروژن اوره خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Cisplatin is a widely used anticancer drug, but it can produce undesirable side effects such as nephrotoxicity. The present study investigated the effect of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) on cisplatin-induced nephrotoxicity in mice. A single dose of cisplatin (45 mg/kg, i.p.) significantly elevated the levels of blood urea nitrogen, serum creatinine, and the kidney to body weight ratio, but the pretreatment of xanthorrhizol (200 mg/kg/day, per os) for 4 days significantly attenuated the cisplatin-induced nephrotoxicity. The preventive effect of xanthorrhizol was more efficacious than that of curcumin with the same amount (200 mg/kg). However, this effect seemed not to be related with the ability of xanthorrhizol to regulate the DNA-binding activities of transcription factors such as nuclear factor-kappaB (NF-κB) and activator protein 1 (AP-1). This is first time the preventive effect of xanthorrhizol on cisplatin-induced nephrotoxicity has been demonstrated, and these data suggest that the administration of xanthorrhizol is a promising approach in the treatment of nephrotoxicity caused by cisplatin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 1, January 2005, Pages 117-122
Journal: Food and Chemical Toxicology - Volume 43, Issue 1, January 2005, Pages 117-122
نویسندگان
Seong Hwan Kim, Kyoung Ok Hong, Jae Kwan Hwang, Kwang-Kyun Park,