کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9032201 | 1131738 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Kainate Receptors and Mossy Fiber LTP
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
There is considerable interest in understanding long-term potentiation (LTP) of glutamatergic synaptic transmission because the molecular mechanisms involved in its induction and expression are believed to be critical for learning and memory. There are two distinct forms of LTP. One type is triggered by synaptic activation of NMDA receptors and the other is NMDA receptor-independent. The latter type of LTP has been mostly studied at mossy fiber/CA3 synapses. Here we summarise some of our recent studies concerning the mechanisms of the induction of the NMDA receptor-independent form of LTP at these CA3 synapses. This form of LTP is triggered by the synaptic activation of kainate receptors. We also address the importance of Ca2+ availability in the extracellular environment and the release of Ca2+ from intracellular stores for this form of LTP.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 26, Issue 5, October 2005, Pages 769-777
Journal: NeuroToxicology - Volume 26, Issue 5, October 2005, Pages 769-777
نویسندگان
Zuner A. Bortolotto, Robert Nistico, Julia C. More, David E. Jane, Graham L. Collingridge,