کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9034482 1562440 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Protective effects of Vitamin E on endocrine disruptors, PCB-induced dopaminergic neurotoxicity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Protective effects of Vitamin E on endocrine disruptors, PCB-induced dopaminergic neurotoxicity
چکیده انگلیسی
Treatment with PCB: (1) decreased the extracellular dopamine level in rat striatum, (2) increased p-nNOS expression both in rat striatal tissue and in CATH.a cells, (3) reduced the cell viability of, and (4) increased LDH release by CATH.a cells. However, Vitamin E showed a protective effect against PCB-induced toxicity and downregulation of the extracellular dopamine level. These results indicate that Vitamin E may have neuroprotective effects by inhibiting PCB-induced nNOS phosphorylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 216, Issues 2–3, 15 December 2005, Pages 140-146
نویسندگان
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