کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9034711 | 1132637 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nitric oxide signalling and cellular adaptations to changes in oxygenation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Fluctuations in oxygen (O2) levels characterise the cellular microenvironment in physiological and pathological processes such as placentation and malignant progression. Cells adapt to such changes in oxygenation by modifying gene expression, thereby regulating a spectrum of functions. Recent studies indicate that an important mechanism by which cells adapt to changes in oxygenation involves modifications in endogenous nitric oxide (NO) signalling. The effect of oxygen on the NO pathway involving cyclic guanosine monophosphate (cGMP)-dependent signalling appears to play a critical role in the regulation of cellular phenotypes. This specific NO signalling pathway may also operate in conjunction with gene expression regulated by the transcription molecule hypoxia inducible factor 1 (HIF-1). Thus, NO is emerging as a novel regulator of oxygen-sensitive phenotypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 208, Issue 2, 15 March 2005, Pages 235-248
Journal: Toxicology - Volume 208, Issue 2, 15 March 2005, Pages 235-248
نویسندگان
Lynne-Marie Postovit, Richard Sullivan, Michael A. Adams, Charles H. Graham,