کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9034930 | 1562444 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of type II pyrethroid cyhalothrin on peritoneal macrophage activity in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of type II pyrethroid cyhalothrin on peritoneal macrophage activity in rats Effects of type II pyrethroid cyhalothrin on peritoneal macrophage activity in rats](/preview/png/9034930.png)
چکیده انگلیسی
Synthetic type II pyrethroids induce anxiety, immunosuppressive or, alternatively, immunostimulatory effects in laboratory animals. Macrophages are known to be key elements in cellular immune responses. The present study was designed to investigate the in vivo effects of cyhalothrin (0.6, 1.0 and 3.0 mg/kg/once daily for 7 days) on macrophage activity. The in vitro effects of cyhalothrin (100 nM, 1 and 10 μM) were also analyzed to verify a possible direct action of this pyrethroid on macrophage. Results showed that in vivo cyhalothrin treatment: (1) decreased macrophage spreading and phagocytosis indexes; (2) decreased macrophage nitric oxide (NO) production; (3) did not change spontaneous or PMA-induced macrophage H2O2 release. The no effect level dose (NOEL) obtained for cyhalothrin on macrophage activity was 0.6 mg/kg/day. In-vitro data showed that cyhalothrin decreased (1) macrophage NO production and (2) macrophage spontaneus and PMA-induced H2O2 releases. The present results were explained through an indirect action for cyhalothrin on macrophage activity via hypothalamic pituitary adrenals (HPA) axis activation. A direct effect for cyhalothrin on macrophage, most probably through an action on Na+ membrane channels, was also suggested. Finally, it is possible that both direct and indirect mechanisms would be involved with cyhalothrin effects on macrophage activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 212, Issues 2â3, 1 September 2005, Pages 98-106
Journal: Toxicology - Volume 212, Issues 2â3, 1 September 2005, Pages 98-106
نویسندگان
D.A. Righi, J. Palermo-Neto,