کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9034944 | 1562444 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The brain is a target organ after acute exposure to depleted uranium
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The brain is a target organ after acute exposure to depleted uranium The brain is a target organ after acute exposure to depleted uranium](/preview/png/9034944.png)
چکیده انگلیسی
The health effects of depleted uranium (DU) are mainly caused by its chemical toxicity. Although the kidneys are the main target organs for uranium toxicity, uranium can also reach the brain. In this paper, the central effects of acute exposure to DU were studied in relation to health parameters and the sleep-wake cycle of adult rats. Animals were injected intraperitoneally with 144 ± 10 μg DU kgâ1 as nitrate. Three days after injection, the amounts of uranium in the kidneys represented 2.6 μg of DU gâ1 of tissue, considered as a sub-nephrotoxic dosage. The central effect of uranium could be seen through a decrease in food intake as early as the first day after exposure and shorter paradoxical sleep 3 days after acute DU exposure (â18% of controls). With a lower dosage of DU (70 ± 8 μg DU kgâ1), no significant effect was observed on the sleep-wake cycle. The present study intends to illustrate the fact that the brain is a target organ, as are the kidneys, after acute exposure to a moderate dosage of DU. The mechanisms by which uranium causes these early neurophysiological perturbations shall be discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 212, Issues 2â3, 1 September 2005, Pages 219-226
Journal: Toxicology - Volume 212, Issues 2â3, 1 September 2005, Pages 219-226
نویسندگان
P. Lestaevel, P. Houpert, C. Bussy, B. Dhieux, P. Gourmelon, F. Paquet,