کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9035155 | 1132671 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Strenuous exercise aggravates MDMA-induced skeletal muscle damage in mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Charles-River mice were distributed into four groups: Control (C), exercise (EX), MDMA treated (M), and M + EX. The treated animals received an i.p. injection (10Â mg/kg) of MDMA (saline for C and EX), and the exercise consisted of a 90Â min level run at a velocity of 900Â m/h, immediately after the MDMA or saline administration. Body temperature was recorded every 30Â min via subcutaneous implanted transponder. Animals were sacrificed 1.5, 25.5, and 49.5Â h after i.p. injection and the soleus muscles were removed and processed for light and electron microscopy. The MDMA-treated animals showed a significant increase in body temperature (similar in M and M + EX groups), reaching the peak 90Â min after i.p. administration; their temperature remained higher than control for more than 5Â h. The EX group evidenced a similar and parallel, yet lower temperature increase during exercise and recovery. Morphological signs of damage were rarely encountered in the EX group; they were more pronounced in M group and even aggravated in M + EX group. In conclusion, MDMA and exercise per se increased body temperature but in conjunction did not have a cumulated effect. However, ecstasy and concomitant physical activity might severely accumulate with regard to skeletal muscle toxicity and may lead to rhabdomyolysis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 206, Issue 3, 31 January 2005, Pages 349-358
Journal: Toxicology - Volume 206, Issue 3, 31 January 2005, Pages 349-358
نویسندگان
José A. Duarte, Anabela Leão, José Magalhães, António Ascensão, Maria L. Bastos, Francisco L. Amado, Laura Vilarinho, Dulce Quelhas, Hans J. Appell, Félix Carvalho,