Does dietary ornithine α-ketoglutarate supplementation protect the liver against ischemia-reperfusion injury?

Dietary OKG administration had only a limited effect in this model of mild hepatic I-R, leading mainly to reduced TNFα production. As the content of lipid peroxidation products was not modified, it seems that OKG acts on the inflammatory response rather than on oxidative reactions. This action can tentatively be attributed to the role of OKG as a glutamine precursor rather than to the synthesis of arginine and nitric oxide.