Les aéroallergènes chez le sujet non allergique : quels mécanismes ?

Non-allergic individuals are in contact with the same allergens as allergic individuals but their immune response to these allergens is one of tolerance, the mechanisms of which must be understood in oder to develop effective immunotherapy. Recent experimental reports have described several subpopulations of regulatory T cells (Tr1, Th3, Treg) that play an important role in peripheral tolerance. The mechanism of this tolerance depends on the effects of IL-10 and TGF-β, as well as on the inhibitory effect of membrane molecules such as ICOS and CTLA4. It has been demonstrated in non-allergic individuals that CD4+CD25+ T regulatory cells can inhibit both T cell proliferation and IL-5 production, whereas this T cell subpopulation is deficient in allergic individuals.