Monitorización del tratamiento con tiroxina en el hipotiroidismo primario y central

Monitoring of central hypothyroidism is performed through free T4 determination and levels should be maintained in the upper third of the normal range. Free T3 may add sensitivity in the detection of cases of suboptimal treatment. Clinical findings, although fundamental in patient follow-up, are highly nonspecific in the detection of over- and under-dosing. In central hypothyroidism, sometimes other biochemical parameters such as the interleukin-2 soluble receptor can be useful in detecting cases of suboptimal treatment.