کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9113136 | 1156212 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Melatonin prevents testosterone-induced suppression of immune parameters and splenocyte proliferation in Indian tropical jungle bush quail, Perdicula asiatica
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
During reproductive inactive phase (winter months) peripheral high melatonin and low testosterone was noted in male Indian tropical bird, Perdicula asiatica. During this phase exogenous testosterone (1 mg/100 g Bwt./day) suppressed the immune parameters [spleen weight, total leukocyte count (TLC), lymphocyte count (LC), and percent stimulation ratio (% SR)] and depleted splenic cellular density, while melatonin (25 μg/100 g Bwt./day) restored the immune parameters and splenic cellular density to the level of control birds. In vitro suppression of splenocyte proliferation by testosterone (3 ng/ml) was also reversed by melatonin (500 pg/ml) supplementation. Therefore, high melatonin in circulation during the reproductive inactive phase acts as immunostimulator and is of high adaptive significance to this bird for survival during the adverse conditions of season and reproductive phase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 141, Issue 3, 1 May 2005, Pages 226-232
Journal: General and Comparative Endocrinology - Volume 141, Issue 3, 1 May 2005, Pages 226-232
نویسندگان
Shiv Shankar Singh, Chandana Haldar,