کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9127011 | 1160193 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic features of Khoton Mongolians revealed by SNP analysis of the X chromosome
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کلمات کلیدی
TaqMan assayMCMCMedian-joiningMarkov chain Monte Carlo - زنجیره مارکف مونت کارلوPopulation structure - ساختار جمعیتLinkage disequilibrium - عدم تعادل پیوستگیMongolian - مغولیprincipal component - مولفه های اصلیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیneighbor-joining - پیوستن همسایهSNP - چندریختی تک-نوکلئوتیدX chromosome - کروموزوم X
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Genetic features of Khoton Mongolians revealed by SNP analysis of the X chromosome Genetic features of Khoton Mongolians revealed by SNP analysis of the X chromosome](/preview/png/9127011.png)
چکیده انگلیسی
The Khoton Mongolian population is a small and relatively isolated ethnic group residing predominantly in the northwestern part of Mongolia. A recent genetic study of the Y chromosome revealed that the major Mongolian ethnic groups have a relatively close genetic affinity to populations in the northern part of East Asia, while the Khoton population reflected an apparent genetic differentiation from the other Mongolian populations. To further investigate the genetic features of the Khoton and the other Mongolian populations, we analyzed the single nucleotide polymorphisms (SNPs) in the Xq13.3 region, which is thought to have an extremely low level of recombination in the human X chromosome. We found that the frequency distribution of Xq13.3 haplotypes in the Khoton population was substantially different from those in three other Mongolian populations (Khalkh, Uriankhai, and Zakhchin). The same relationship was also revealed by the results from the population tree and principal-component (PC) analysis based on the allele frequencies. These results are largely consistent with the hypothesis that the Khoton population descended from a nomadic tribe of Turkish origin, which has been supported by previous anthropological, historical, and Y-chromosome studies. However, the population structure analysis produced an additional finding, namely, that the Khoton population is likely to be an admixed population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 357, Issue 2, 12 September 2005, Pages 95-102
Journal: Gene - Volume 357, Issue 2, 12 September 2005, Pages 95-102
نویسندگان
Toru Katoh, Shuhei Mano, Batmunkh Munkhbat, Kenichi Tounai, Ganjuur Oyungerel, Gue-Tae Chae, Hoon Han, Guan-Jun Jia, Katsushi Tokunaga, Namid Munkhtuvshin, Gen Tamiya, Hidetoshi Inoko,