کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9137755 1162495 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exosome release by reticulocytes-An integral part of the red blood cell differentiation system
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Exosome release by reticulocytes-An integral part of the red blood cell differentiation system
چکیده انگلیسی
Reticulocyte maturation into erythrocytes is the final step of erythropoiesis that occurs in the blood circulation. This terminal differentiation period corresponds to a cellular remodeling phase following expulsion of the nucleus into the bone marrow. Among other events, this remodeling leads to the disappearance of intracellular organelles and acquisition of the typical cellular biconcave form. Here, we propose that exosome biogenesis and secretion, which contributes to net loss of the cell surface membrane via selective vesicular membrane secretion, is also closely interconnected with upstream (nucleus expulsion), accompanying (mitoptosis) and downstream (vesicle clearance) events.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 35, Issue 1, July–August 2005, Pages 21-26
نویسندگان
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