کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9140001 1163390 2005 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rubrerythrin and peroxiredoxin: Two novel putative peroxidases in the hydrogenosomes of the microaerophilic protozoon Trichomonas vaginalis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Rubrerythrin and peroxiredoxin: Two novel putative peroxidases in the hydrogenosomes of the microaerophilic protozoon Trichomonas vaginalis
چکیده انگلیسی
The parasitic flagellate Trichomonas vaginalis contains hydrogenosomes, anaerobic organelles related to mitochondria, that generate ATP from the fermentative conversion of pyruvate to acetate, CO2 and molecular hydrogen. Although an essentially anaerobic organism, Trichomonas encounters low oxygen concentrations in its natural habitat and has to protect itself, and especially the oxygen-sensitve enzymes of hydrogenosomal metabolism, from oxidative damage. We have identified two novel proteins in the hydrogenosomal proteome with strong similarity to two putative prokaryotic peroxidases, rubrerythrin and periplasmic thiol peroxidase. Both proteins have previously been found in many prokaryotes but were not known from eukaryotes, suggesting a significant prokaryotic component in the oxygen-detoxification system of trichomonad hydrogenosomes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Biochemical Parasitology - Volume 142, Issue 2, August 2005, Pages 212-223
نویسندگان
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