کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9141678 | 1163865 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bcl6 regulates Th2 type cytokine productions by mast cells activated by FcÉRI/IgE cross-linking
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
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چکیده انگلیسی
Bcl6-deficient (Bcl6â/â) mice displayed Th2 type inflammation, which caused by abnormality of non-lymphoid cells. However, initiators for the Th2 type inflammation were not clear. In order to elucidate the initiators, we investigated property and function of mast cells derived from Bcl6â/â mice. Mast cells were developed from bone marrow cells cultured with IL-3 (BMMCs). Although the development of BMMCs from Bcl6â/â mice was similar to that from wild-type mice, proliferation of Bcl6â/â BMMCs stimulated with IL-3 was slightly lower than that of wild-type BMMCs. When these BMMCs were stimulated by FcÉRI/IgE cross-linking, Bcl6â/â BMMCs produced Th2 cytokines more than wild-type BMMCs did. Thus, Bcl6â/â mast cells are one of the initiators for Th2 type inflammation in Bcl6â/â mice, and Bcl6 may be a molecular target for Th2 type allergic diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 42, Issue 12, August 2005, Pages 1453-1459
Journal: Molecular Immunology - Volume 42, Issue 12, August 2005, Pages 1453-1459
نویسندگان
Yuichiro Ohtsuka, Masafumi Arima, Lisa Fujimura, Haifeng Li, Akemi Sakamoto, Yoshitaka Okamoto, Takeshi Tokuhisa,