کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9142068 1163895 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proteomic analysis of human natural killer cells: insights on new potential NK immune functions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Proteomic analysis of human natural killer cells: insights on new potential NK immune functions
چکیده انگلیسی
Applying high-throughput proteomic analysis of mammalian cells can facilitate the identification of a large number of proteins expressed in the examined samples. Moreover, extensive research efforts are being made to perform large-scale characterization of membrane proteins. Here we use mass spectrometry-based proteomic strategy to characterize protein expression in membrane-enriched fractions derived from human NK lymphoma cell line YTS. This query yielded a list of over 1000 identified proteins, and provided us with new insights on NK cell biology. We highlight the expression of CD86 on YTS and its ability to co-stimulate TCR responses of human CD4+ T-cells, providing an unexpected link between innate and adaptive immune systems.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 42, Issue 4, February 2005, Pages 425-431
نویسندگان
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