کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9148781 1166110 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Whole body hyperthermia in mice confers heat shock protein-dependent radioresistance of their bone marrow and thymocytes
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Whole body hyperthermia in mice confers heat shock protein-dependent radioresistance of their bone marrow and thymocytes
چکیده انگلیسی
Here we studied how whole body hyperthermia in mice affects radiosensitivity of their tissues and cells. To examine a contribution of heat shock proteins (Hsps) we used Quercetin, an inhibitor of the Hsp induction. Bone marrow and thymocytes did become more radioresistant in heat-preconditioned mice. The radioprotection was well manifested in 18-26 h after hyperthermia and was strongly suppressed in Quercetin-injected mice. The revealed correlation between the intracellular Hsp content and radioresistance suggests the radioprotective potential of stress-inducible Hsps. Thus, our finding points out new ways for artificial modulation of the in vivo radiation effects by manipulating the Hsp expression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Thermal Biology - Volume 30, Issue 7, October 2005, Pages 511-517
نویسندگان
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