Latex D-dimer Signal in In Situ Femoral Vein Thrombus in Swine and Effect of Minidose Exogenous Tissue Plasminogen Activator Bolus

We conclude the following: (1) in situ femoral vein clot formation does not elevate d-dimer signal for 1 h after ligature release; (2) minidose t-PA boluses of 0.8 mg and 4 mg significantly elevated the latex d-dimer signal above baseline; and (3) there is a potential role of minidose t-PA in enhancing the d-dimer signal in in situ deep venous thrombosis.