Effects of experimental hyperandrogenemia on the female rat reproductive axis: Suppression of progesterone-receptor messenger RNA expression in the brain and blockade of luteinizing hormone surges

Our findings are consistent with the hypothesis that hyperandrogenic interference in the release of preovulatory LH surges is mediated by the suppressive effects of androgens on PR expression in POA-hypothalamic tissue. These findings may have important implications in the understanding of reproductive dysregulation in female hyperandrogenic syndromes, including polycystic ovary syndrome.