Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37°C and 42°C

Progressively greater block of hERG and prolongation of APD by erythromycin was observed at temperatures between 36 and 42°C. Temperature-dependent block of IhERG is explained by temperature-dependent access of erythromycin to the intracellular binding site at F656.