Effect of increasing doses of aspirin on platelet function as measured by PFA-100 in patients with diabetes

Although, a daily dose of 100 mg aspirin effectively inhibited platelet function in a majority of diabetics, a considerable proportion of patients showed a greater platelet inhibition with the use of 300 mg aspirin. The PFA-100™ closure time may be used to separate those patients who require a higher dose of aspirin to achieve desired antiplatelet effect.