کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9185466 | 1183184 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Varying the ratio of dietary nâ6/nâ3 polyunsaturated fatty acid alters the tendency to thrombosis and progress of atherosclerosis in apoEâ/â LDLRâ/â double knockout mouse
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Varying the ratio of dietary nâ6/nâ3 polyunsaturated fatty acid alters the tendency to thrombosis and progress of atherosclerosis in apoEâ/â LDLRâ/â double knockout mouse Varying the ratio of dietary nâ6/nâ3 polyunsaturated fatty acid alters the tendency to thrombosis and progress of atherosclerosis in apoEâ/â LDLRâ/â double knockout mouse](/preview/png/9185466.png)
چکیده انگلیسی
We have investigated the influence of dietary nâ6/nâ3 (ù-6/ù-3) polyunsaturated fatty acid-balance on the tendency to arterial thrombosis and the progress of atherosclerosis in apoEâ/â LDLRâ/â double knockout mouse. Homozygous apoEâ/â LDLRâ/â double knockout mouse (DKO mice, 129XC57BL/6J background) and male C57BL/6 mice aged 6 weeks were divided into four groups. Each group was fed a diet containing a different nâ6/nâ3 ratio (Group l: 0.29; Group 2: 1.43; Group 3: 5.00; Group 4: 8), prepared with high linolenic (LNA) flaxseed oil (nâ3 rich) and high linoleic (LA) safflower oil (nâ6 rich). There were no statistical differences in the gain in body weight between the four groups. After 16 weeks, plasma triglyceride and LDL levels in Group 1 were significantly lower than in the other groups. Conversely, HDL was the highest. After 8 and 16 weeks, the tendency to arterial thrombosis was assessed using a He-Ne laser-induced thrombosis model. The degree of atherosclerosis was measured using the entire aorta method employing image analysis software. The nâ6/nâ3 ratio had a dose-dependent antithrombotic effect (thrombus volume decreased 23%, Group 1 vs. Group 4), In addition, the extent of atherosclerosis was less in the animals fed a low nâ6/nâ3 ratio compared with the high nâ6/nâ3 ratio group (atherosclerotic area decreased 40%, Group 1 vs. Group 4). The lowest nâ6/nâ3 ratio tested (0.29) was the most effective in suppressing the thrombotic and atherosclerotic parameters in these DKO mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 116, Issue 5, 2005, Pages 393-401
Journal: Thrombosis Research - Volume 116, Issue 5, 2005, Pages 393-401
نویسندگان
T. Yamashita, E. Oda, T. Sano, T. Yamashita, Y. Ijiru, J.C. Giddings, J. Yamamoto,