کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9185629 | 1579210 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anticoagulant action of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord and adult plasma: an in vitro examination
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کلمات کلیدی
UFHGPRPPPACKTFPIXimelagatránLMWHDTICTMETPIC50APTTantithrombin - آنتی ترومبینEDTA - اتیلن دی آمین تترا استیک اسید ethylenediaminetetra-acetic acid - اسید اتیلنیدین تترا استیکTAT - تاتIntravenous - داخل وریدیsubcutaneous - زیر جلدیCoagulation factor - عامل انعقادTissue factor - عامل بافتprothrombin fragment 1.2 - قطعه پروتروببین 1.2direct thrombin inhibitor - مستقیم مهار کننده ترومبینMelagatran - ملغاترانTissue factor pathway inhibitor - مهار کننده پروتئین بافتیunfractionated heparin - هپارین غیر اشباع شدهlow-molecular-weight heparin - هپارین کم وزن مولکولیendogenous thrombin potential - پتانسیل ترومبین درونیUmbilical cord plasma - پلاسمای طناب نخاعی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anticoagulant action of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord and adult plasma: an in vitro examination Anticoagulant action of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord and adult plasma: an in vitro examination](/preview/png/9185629.png)
چکیده انگلیسی
Introduction:This study was performed to compare the anticoagulant activity of melagatran, the active form of the oral direct thrombin inhibitor ximelagatran, in umbilical cord plasma with that in adult plasma. In contrast with the most frequently administered anticoagulants, the heparins, melagatran acts independently of antithrombin (AT). As a consequence, administration of melagatran is of special interest in neonates, who have physiologically low levels of AT. Materials and methods: Plasma samples were activated under high (as used in standard clotting assays) and low (more comparable with the physiological milieu) coagulant challenge. In the absence of melagatran, adult plasma clotted significantly faster than umbilical cord plasma under high coagulant challenge. Conversely, under low coagulant challenge, clotting of adult plasma was significantly delayed compared with umbilical cord plasma. For both high and low coagulant challenges, clotting times increased and prothrombin fragment 1.2 and thrombin-antithrombin (TAT) formation decreased with melagatran in a concentration-dependent fashion in umbilical cord and adult plasma. With increasing melagatran concentrations, the quotient between prothrombin fragment 1.2 and TAT formation increased in adult and umbilical cord plasma under both high and low coagulant challenges. Results and conclusions: Our in vitro results cannot be directly extrapolated to clinical efficacy, but assessing the degree of inhibition of thrombin generation may be a useful surrogate for selecting effective doses of ximelagatran for in vivo studies in neonates with thromboembolic complications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 115, Issues 1â2, 2005, Pages 135-142
Journal: Thrombosis Research - Volume 115, Issues 1â2, 2005, Pages 135-142
نویسندگان
Martin Koestenberger, Siegfried Gallistl, Gerhard Cvirn, Katrin Baier, Bettina Leschnik, Wolfgang Muntean,