کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9186147 1183683 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of the Voltage-Gated Cardiac Sodium Channel Nav1.5 by Interacting Proteins
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Regulation of the Voltage-Gated Cardiac Sodium Channel Nav1.5 by Interacting Proteins
چکیده انگلیسی
Nav1.5, the major cardiac voltage-gated Na+ channel, plays a central role in the generation of the cardiac action potential and in the propagation of electrical impulses in the heart. Its importance for normal heart function has been recently exemplified by reports of numerous mutations found in the gene SCN5A-which encodes Nav1.5-in patients with various pathologic cardiac phenotypes, indicating that even subtle alterations of Nav1.5 cell biology and function may underlie human diseases. Similar to other ion channels, Nav1.5 is most likely part of dynamic multiprotein complexes located in the different cellular compartments. This review focuses on five intracellular proteins that have been recently reported to directly bind to and contribute to the regulation of Nav1.5: ankyrin proteins, fibroblast growth factor homologous factor 1B, calmodulin, Nedd4-like ubiquitin-protein ligases, and syntrophin proteins.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Cardiovascular Medicine - Volume 15, Issue 1, January 2005, Pages 35-40
نویسندگان
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