کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9186308 1183851 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of Weibel-Palade Body Exocytosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Regulation of Weibel-Palade Body Exocytosis
چکیده انگلیسی
Weibel-Palade bodies (WPBs) are endothelial granules that store von Willebrand factor (VWF), P-selectin, and other vascular modulators. Endothelial cells secrete WPBs in response to vascular injury, releasing VWF, which triggers platelet rolling, and externalizing P-selectin, which activates leukocyte trafficking. Endothelial exocytosis is one of the earliest responses to vascular damage and plays a pivotal role in thrombosis and inflammation. This review examines the regulation of WPB exocytosis-the exocytic machinery, activators, and inhibitors of exocytosis-and speculates about the development of novel anti-exocytic drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Cardiovascular Medicine - Volume 15, Issue 8, November 2005, Pages 302-308
نویسندگان
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