A screen of candidate genes and influence of β2-adrenergic receptor genotypes in postural tachycardia syndrome

Of the candidate genes screened, none harbored a SNP considered to be causally related to POTS. There was significant association of HR and DBP with SNPs of the gene encoding β2AR; Gly16 or Glu27 could aggravate orthostatic tachycardia by excessive venous pooling.