کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9186586 | 1579590 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Excitatory actions of motilin on myenteric neurons of the guinea-pig small intestine
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Motilin is considered as a key factor in controlling interdigestive migrating contractions. The present electrophysiological experiments were performed in vitro to examine actions of motilin on myenteric neurons of guinea-pigs after 18-h fasting period. Superfusion of motilin depolarized both S and AH neurons; the lowest effective concentration was 10 nM, and motilin depolarization was observed in 9 of 23 S neurons and in 5 of 25 AH neurons. The motilin depolarizations were associated with an increase in neuronal input resistance. The motilin responses were preserved in Ca2+ free/high Mg2+ solution in which no Ca2+ dependent synaptic transmission occurred. The reversal potential of the motilin responses was estimated about â95 mV, close to the equilibrium potential for K+. Furthermore, muscarinic depolarizations were blocked during the motilin responses. All of these indicated that motilin directly excited myenteric neurons mainly by inactivating K+ channels. It is concluded that motilin might modulate neuronal excitability of the myenteric plexus, leading to the control of interdigestive migrating contractions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 118, Issues 1â2, 31 March 2005, Pages 88-92
Journal: Autonomic Neuroscience - Volume 118, Issues 1â2, 31 March 2005, Pages 88-92
نویسندگان
Yoshifumi Katayama, Kiyotoshi Ooishi, Keiji Hirai, Tomoo Homma, Yumi Noda,