کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194470 | 1580501 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α-Tocopherol attenuates NFκB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
This study was conducted to determine if α-tocopherol facilitates recovery from lipopolysaccharide (LPS)-induced sickness behavior through a NFκB-dependent mechanism. In the first study, 3 daily intraperitoneal (i.p.) injections of α-tocopherol (20 mg) improved recovery from sickness behavior induced by i.p. injected LPS. Furthermore, α-tocopherol pretreatment attenuated LPS-activated NFκB and pro-inflammatory cytokine production in brain. In addition, inhibiting NFκB activity in the brain specifically by ICV injection of a NFκB decoy prior to LPS, significantly accelerated recovery from LPS-induced sickness behavior. Taken together, these data indicate α-tocopherol modulates sickness behavior and inflammatory cytokine production in the brain through an NFκB-dependent pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 169, Issues 1â2, December 2005, Pages 97-105
Journal: Journal of Neuroimmunology - Volume 169, Issues 1â2, December 2005, Pages 97-105
نویسندگان
J.P. Godbout, B.M. Berg, C. Krzyszton, R.W. Johnson,