کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9194498 1580500 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis
چکیده انگلیسی
Sera from patients with myasthenia gravis (MG) were screened for autoantibodies to skeletal muscle-specific antigens by immunoprecipitation assay, using rhabdomyosarcoma and leukemia cell lines. Eleven of 61 MG sera immunoprecipitated a rhabdomyosarcoma-specific 70-kDa protein, which was identified as the voltage-gated K+ channel 1.4 (KV1.4). This antibody specificity was not detected in 30 patients with polymyositis/dermatomyositis, 9 with thymoma alone, or 30 healthy controls. Clinical features associated with anti-KV1.4 antibody included bulbar involvement, myasthenic crisis, thymoma, myocarditis, and QT prolongation on electrocardiogram. These findings suggest that anti-KV1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 170, Issues 1–2, 30 December 2005, Pages 141-149
نویسندگان
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