کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9194498 | 1580500 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel autoantibodies to a voltage-gated potassium channel KV1.4 in a severe form of myasthenia gravis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Sera from patients with myasthenia gravis (MG) were screened for autoantibodies to skeletal muscle-specific antigens by immunoprecipitation assay, using rhabdomyosarcoma and leukemia cell lines. Eleven of 61 MG sera immunoprecipitated a rhabdomyosarcoma-specific 70-kDa protein, which was identified as the voltage-gated K+ channel 1.4 (KV1.4). This antibody specificity was not detected in 30 patients with polymyositis/dermatomyositis, 9 with thymoma alone, or 30 healthy controls. Clinical features associated with anti-KV1.4 antibody included bulbar involvement, myasthenic crisis, thymoma, myocarditis, and QT prolongation on electrocardiogram. These findings suggest that anti-KV1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 170, Issues 1â2, 30 December 2005, Pages 141-149
Journal: Journal of Neuroimmunology - Volume 170, Issues 1â2, 30 December 2005, Pages 141-149
نویسندگان
Shigeaki Suzuki, Takashi Satoh, Hidekata Yasuoka, Yasuhito Hamaguchi, Kortaro Tanaka, Yutaka Kawakami, Norihiro Suzuki, Masataka Kuwana,